What makes SESHA SKIN THERAPY stand apart is our patented delivery system, Permeation Enhancement Technology (PET™).

PET™ works by increasing the solubility parameter of the skin so when larger-molecule, active ingredients are combined with PET™, they are able to pass between the skin cell barrier to reach the deeper layers of the skin. This is critical because the surface of the skin, the epidermis, is composed of dying or already dead cells, so the key to healthy skin must start from below. The versatility of PET™ allows us to combine nutrients that work together as a networking system in providing you the full benefits of each individually picked ingredient.

Because PET™ belongs to a family of compounds originally found in nature, PET™ also passes the stringent requirements of the FDA to be considered GRAS (Generally Regarded As Safe), and is non-toxic, non-irritating and non-allergenic.

Clinical studies show that 260-350% more vitamins are able to pass through the epidermis with PET™ and that our skin therapy formulations are more than twice as effective than other leading products in reducing the signs of skin damage and aging.

As AGEs build up they reduce the flexibility, elasticity, and functionality of these proteins. On the skin, AGEs perpetuate cell death and increase the death rate of fibroblasts. While this is a natural phenomenon that rids the body of damaged and dying cells, AGEs can accelerate cell death and kill healthy proteins. Therefore, glycation compromises the structure of the skin by preventing collagen and elastin proteins from functioning properly and then damaging the intracellular matrix that forms the structure of the skin. These two processes contribute to the deterioration of collagen and elastin, the thinning of the skin, the production of wrinkles and the loss of skin tone. In addition, glycation stimulates inflammatory cytokins-IL-6, TNFα, making the skin appear rough, blemished, and inflamed.

According to Dr. Peter Pugliese, several studies suggest that certain ingredients such as carnosine and aminoguanidine may inhibit glycation by preventing the course of the Maillaird reaction. Carnosine, a di-peptide antioxidant that mimics the structure of Vitamin E, seems to prevent the protein and sugar molecules from entering into the Maillard reaction. By bonding with proteins and carbonylated molecules, carnosine inhibits the potential cross-linking of glycated materials. Carnosine also protects healthy proteins from being damaged by AGEs already accumulated.

Aminoguanidine is another active that is reported to minimize glycation by inhibiting the formation and cross-linking of AGEs. Clinical studies show that aminoguanidine slows the progression of certain diseases such as diabetic kidney disease. Although glycation inhibitors are still being researched, active measures can be taken to slow and reduce the negative effects of glycation. First, because glycation is perpetuated by heat, wearing sunscreen, limiting the amount of direct contact with UV rays, and avoiding the eating food cooked at high temperatures can help fight the effects of glycation. Also, cutting down on sugar (including fruit) in your diet limits the glucose or fructose that can bind to proteins and reduces the cross-linking that leads to AGEs. Finally, supplementing your diet with carnosine and using skincare products containing carnosine and aminoguanidine can help reduce the effects of glycation in your body.

SESHA SKIN THERAPY offers the protection of carnosine in its Elixir Day Repair and in the new CLINICAL Protect/Repair – 30 Day Emulsion. The CLINICAL line also features Advanced Antioxidant Cream with the dual benefits of carnosine and aminoguanidine.

With the health & skincare industry saturated with the hottest and newest trends, the power of antioxidants, the foundation and arguably the most effective means of dramatically improving the body, is being diluted.  Most of us are aware that antioxidants benefit our health and our skin, but to some, antioxidants may seem like a thing of the past.  However, antioxidants are not a trend or passing phase in fighting the aging process.  
SESHA Active Ingredients

When taken alone, each of the five “powerhouse “ plays a significant role within the cell molecules.  For example, vitamin E is excellent fighting heart-related diseases, oxidation from UV rays and various forms of cancer.  Vitamin C enhances the immune system and helps the skin produce collagen and increases the turnover rate of the outer skin layer.  The most remarkable phenomenon in the relationship between vitamins C & E is that vitamin C possesses the ability to recycle “used” vitamin E to extend the beneficial effects of a vitamin E molecule.  In other words, after a vitamin E molecule engulfs a free radical and becomes a weak free radical itself, a vitamin C molecule can recharge the vitamin E back to its original antioxidant state.

The ability to recycle used molecules is applicable for all five networking antioxidants.  For instance, adding glutathione, an antioxidant that restores vitamin C and is an excellent antioxidant for detoxification and anti-inflammatory effect. Of the five networking antioxidants, alpha-lipoic acid, in particular, is considered to be a superior antioxidant because of its solubility in both water and oil.  Because water and oil do not mix, most antioxidants can only function in either the core of a cell, which is composed mainly of water or the surrounding fatty oil-based membrane.  However, the unique dual solubility of alpha-lipoic acid allows it to work throughout the entire cell – in both the core and membrane of the cell.  This duality also gives alpha-lipoic acid the ability to regenerate all five of the networking antioxidants, including itself.

SESHA SKIN THERAPY is science made beautiful.  At SESHA, we believe the key to beautiful skin is nourishment.  We deliver skincare products packed with the latest scientific nutrients, powerhouse antioxidant, peptides and botanicals and using our exclusive FDA approved delivery technology to deliver where they are needed most –  below the skin’s surface.  As a result, skin glows, feels fantastic; achieving healthier and more radiant new skin!